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Neuroimaging Data Sharing and Open Brain Science in China: The 5th Annual Event of Chinese Young Scholars for Human Brain Mapping

7/28/2021

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By:  Chao-Gan Yan
The 5th Annual Event of Chinese Young Scholars for Human Brain Mapping was held on June 23, 2021 under the topic of “Neuroimaging data sharing and open brain science in China”. As in previous editions, the goal of this event is to bring together Chinese researchers from the OHBM community to communicate, discuss, and collaborate on cutting edge neuroscience research topics and methods. We invited Professors Ying Han, Jiang Qiu, Sha Tao, Chao-Gan Yan, Chun-Shui Yu, Yu-Feng Zang, Zhan-Jun Zhang, and Xi-Nian Zuo to give talks on open neuroimaging resources in China. ​
PictureThe SILCODE Cohort
Professor Ying Han presented the SILCODE (Sino Longitudinal Study on Cognitive Decline) Cohort research project, which is a multicenter cohort on preclinical Alzheimer's disease (AD) in China. It is part of the Alliance for Preclinical AD in China, belonging to the National Clinical Research Center for Geriatric Disorders. Its sites include more than 180 member hospitals/research institutes across China. The collected data includes demographic information, clinical data, risk factors, neuropsychological tests, blood and urine biomarkers, multimodal MRI biomarkers, glucose mentalism, and amyloid deposition. The main aim of SILCODE is to estimate cognitive decline and establish statistical prediction models for the outcomes of subjective cognitive decline in elderly Chinese people.

Professor Jiang Qiu introduced the Southwest University Longitudinal Imaging Multimodal (SLIM) Brain Data Repository. The dataset comprises a large multi-modal (sMRI, rs-fMRI, DWI, and behavioral), longitudinal (average interval days = 817.87 days) investigation of the neural underpinnings and development of creativity and emotion. The goal of the SLIM was to investigate the neural substrate of individual differences in a variety of psychological traits, mainly the creativity and risk factors of affective disorders, using both the cross-sectional and longitudinal data. ​​
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Southwest University Longitudinal Imaging Multimodal (SLIM) Brain Data Repository
Picture
The Southwest University Adult Life Dataset (SALD)
Furthermore, Professor Qiu introduced the Southwest University Adult Life Dataset (SALD). The SALD comprises a large cross-sectional sample (total scans = 494; age span = 19-80 years) and a multi-modal (sMRI and rs-fMRI) investigation of these neural underpinnings. The goal of the SALD is to understand what a normal brain looks like and how it structurally and functionally changes at each decade of life from age 20 through age 80.
PictureThe Beijing Imaging Genetic Cohort of children’s school functions and brain development
Professor Sha Tao introduced the Beijing Imaging Genetic Cohort of children’s school functions and brain development. Since 2015, they have been conducting an imaging genetic cohort study of school children in Beijing. They aim to depict brain development during school years, review the mutual effects between brain development and school functions, and examine the interaction between genes and school experience, including learning to read, learning a foreign language, and sports or music extracurricular activities. As of May 24th of this year, they have scanned almost 800 children at baseline, more than 470 at follow-up 1, and more than 360 at follow-up 2. The follow-up is ongoing. Furthermore, based on the baseline data, the Chinese pediatric brain templates (6-12 years old) were developed and released in 2019 . Since the end of 2016, a national imaging genetic cohort study of school children has been planned. This national study will be supported by the China brain initiative, planning to follow 30,00 aged 6 to 7 years old children for more than 10 years on their brain and behavior development across various urban and rural areas around China. Now, nearly 30 institutions have joined in this project.

PictureThe REST-meta-MDD Project
Professor Chao-Gan Yan introduced the REST-meta-MDD Project and Brain Imaging Sharing Initiative. To address limited statistical power and analytic heterogeneity, they initiated the REST-meta-MDD Project. Contributions were requested from users of DPARSF, a MATLAB- and SPM-based R-fMRI preprocessing pipeline. Twenty-five research groups from 17 hospitals in China formed the REST-meta-MDD consortium and agreed to share final R-fMRI indices from patients with MDD and matched normal controls from studies approved by local Institutional Review Boards. The consortium contributed 2428 previously collected datasets (1300 MDDs and 1128 NCs). The REST-meta-MDD data entered the unrestricted sharing phase on January 1, 2020. The researchers can perform any analyses of interest while not violating ethics. Furthermore, he introduced the use of the Brain Imaging Sharing Initiative (BISI) to download or share open neuroimaging data.

Professor Chun-Shui Yu presented the Chinese Imaging Genetics Cohort (CHIMGEN). The Chinese Imaging Genetics project has established the largest Chinese neuroimaging genetics cohort and aims to identify genetic and environmental factors and their interactions that are associated with neuroimaging and behavioral phenotypes. This project has collected genomic, neuroimaging, environmental, and behavioral data from over 7306 subjects at 30 centers in China.
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The Chinese Imaging Genetics Cohort
PictureThe Sharing RS-fMRI data for precise localization of the abnormal brain activity
Professor Yu-Feng Zang presented the Sharing RS-fMRI data for precise localization of abnormal brain activity. He proposed that localizing the seizure focus as well as its boundary can help plan intracranial EEG location and seizure focus resection, moreover, localizing the abnormal activity can help define the targets of focused brain stimulation such as deep brain stimulation and transcranial magnetic stimulation. How to precisely locate the abnormal brain activity. There are some inclusion criteria of published papers for high-quality coordinate-based meta-analysis including voxel-level (not region-level) analysis, whole-brain (not partial brain) analysis. And the analytic methods in the region study should be very similar. The analytic methods of the existing meta-analysis papers of neuroimaging studies such as task-fMRI, VBM, PET are very similar. However, for rs-fMRI, the analytic methods vary a lot in most studies. So far, PD and AD/MCI are the most reproducible abnormal activity for a specific brain disorder. Finally, he proposed data sharing and multi-center data analysis are necessary. To locate the abnormal brain activity of brain disorders can guide focused brain stimulation. A small p-value may not increase reproducibility. It can provide a “gold” standard for computation studies to develop new analytic methods. Last, for a single-center study, he strongly encouraged individual maps or at least the t-map without any threshold should be published. ​

Professor Zhan-Jun Zhang introduced the Beijing Aging Brain Rejuvenation Initiative (BABRI) Cohort that was launched in 2008. The project aims to study the neural mechanisms of mild cognitive impairment and dementia and to reveal the potential risk factors. The project plans to build a localized cognitive aging and brain health database covering 10,000 community-based native Chinese elderly subjects (> 50 years old) with periodic follow-up in 20 years. There are 35 cooperating communities and more than 10 hospitals in Beijing. In 2017, the project promoted a nationwide multicenter study on cognitive aging and brain aging that was called the National Consortium project of BABRI.
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The Beijing Aging Brain Rejuvenation Initiative (BABRI) Cohort
PictureThe Chinese Color Nest Project
Professor Xi-Nian Zuo presented the Chinese Color Nest Project (CCNP). This is a long-term lifespan developmental cohort on the human brain and mind. CCNP employs the accelerated longitudinal design to build a lifespan sample of 1,200 healthy people aged from 6 to 85 years old. It comprises three components. The first one is the developing stage (devCCNP), namely ‘Growing Up in China’. The second one is the standardizing stage (stdCCNP), which is also called 3R-BRAIN and designed for the measurement standardization. And the last one is the aging stage (ageCCNP). Furthermore, there will be 6000 pairs of twins across the same lifespan after the initial cohort is completed in the second ten-year phase of the CCNP. By now, the working team has completed two accelerated cohorts in Beijing and Chongqing. Using the CCNP big data, the team charted brain growth in tandem with brain templates at school age. They found that it is necessary to use each specific and affinity matched brain template in brain growth chart analysis. Recently, using the repeated resting-state functional data from CCNP, the team further revealed a developmental shift of cortical connectivity gradient across school ages. ​

During the live discussion session, the speakers briefly summarized the talks and discussed open questions with the audience. Despite the efforts of cohort/datasets accumulated in China, global impact needs to be increased for future studies. Speakers acknowledged that OHBM is an amazing platform for the presentation of these datasets, and they look forward to potential collaborations with interested international investigators.
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